Essay on the effects of different antibiotics on the growth of E.coli
The effects of antibiotics on the growth of Escherichia coli have been found in several studies and some recent studies have also focused on the tolerance and reduced growth levels in bacteria to examine the molecular changes that allow such as change. E. Coli and anti-microbial agents: In a study by Dixon et al (2004), the antibacterial effects of microcystin, which is, a cyanotoxin produced by Microcystis aeruginosa have been discussed. In the presence of microcystin, the inhibitory values for a range of hydrophobic inhibitors were significantly reduced. Dixon and his colleagues studied the direct effects of appropriate concentrations of microcystin on the integrity of bacterial inner and outer membranes and found that the presence of microcystin affects the permeability levels of entero-bacterial outer membranes.
Tolerance to anti-microbial agents in seen in bacteria, which shows a slower growth rate or which no longer, multiplies. This is very common in the E. coli bacteria, which shows a decreased growth rate after being exposed to antibiotics. In clinical infections bacteria tend to multiply slowly and extended periods of anti-microbial chemotherapy are needed to eradicate these organisms and achieve complete cure. Hu and Coates (2005) used transposon mutagenesis to understand the molecular basis of antibiotic tolerance. The authors screened 5000 Escherichia coli mutants to see reductions of kanamycin tolerance in the late stationery phase and found that 4935 mutants were able to grow to the late stationery phase. The mutant KS639 was most sensitive to kanamycin. This variety of mutant showed an increased sensitivity to kanamycin and gentamicin, ciprofloxacin and rifampicin. From the data obtained it was seen that a mutant lacking intergenic regions showed reduced tolerance to kanamycin. The studies show that interegenic regions in the E coli may be responsible for anti-microbial agents.
In a study that tend to examine the…
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Tags: anitbiotics, antibiotics, bacteria, drugs, Escherichia coli, microcystin
